Feline Hybridoma Growth Factor/lnterleukin-6 Activity

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T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor

Interleukin-HP1 (HP1)/IL-6 is a 25-30-kD protein produced by macrophages, fibroblasts, and certain T cell lines. It was originally identified as a mouse growth factor for B cell hybridomas and plasmacytomas, and was recently shown to stimulate growth and differentiation of normal B cells. Here we demonstrate that, in the presence of lectins or anti-T cell receptor antibodies, HP1/IL-6 has a gro...

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ژورنال

عنوان ژورنال: Journal of Leukocyte Biology

سال: 1989

ISSN: 0741-5400

DOI: 10.1002/jlb.46.6.501